Paracetamol 650 mg
Pain and fever are common ailments that can disrupt daily life, whether caused by a headache, muscle ache, or an infection. Paracetamol, also known as acetaminophen, is one of the most widely used medications globally for relieving pain and reducing fever. Its safety, efficacy, and accessibility make it a staple in households and healthcare settings.
Aingo Pharma’s Paracetamol 650 mg Tablets are designed to provide fast, reliable relief from moderate pain and fever, catering to adults and adolescents with a higher dose than standard 500 mg tablets. This blog offers a detailed exploration of paracetamol’s composition, mechanism of action, therapeutic uses, dosage guidelines, safety profile, and unique benefits, with a focus on why Aingo Pharma’s formulation stands out in the market.
With pain and fever being prevalent concerns, particularly in India due to seasonal infections and lifestyle-related conditions, understanding paracetamol’s role is essential. This guide aims to empower readers with knowledge to use paracetamol safely and effectively, ensuring optimal health outcomes.
What Is Paracetamol?
Paracetamol(C8H9NO2) is a non-opioid analgesic and antipyretic medication used to relieve mild to moderate pain and reduce fever. It is a first-line treatment for conditions like headaches, muscle aches, menstrual cramps, toothaches, and fever associated with infections. Unlike non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, paracetamol has minimal anti-inflammatory effects, making it ideal for pain and fever without gastrointestinal irritation.
Key Functions of Paracetamol:
- Pain Relief: Alleviates discomfort from various sources, including headaches, musculoskeletal pain, and post-injury soreness.
- Fever Reduction: Lowers elevated body temperature in infections or inflammatory conditions.
- Safe Profile: Suitable for most age groups when used as directed, with fewer side effects than NSAIDs.
- Non-Sedating: Does not cause drowsiness, allowing normal daily activities.
Aingo Pharma’s Paracetamol 650 mg IP Tablets (Aincol-650) offer a higher dose for enhanced efficacy in adults, ensuring rapid symptom relief with a single tablet. These tablets are particularly valuable for managing acute pain and fever episodes in busy lifestyles.
Why Understanding Paracetamol’s Composition Matters
The composition of paracetamol tablets determines their efficacy, safety, and tolerability. The active ingredient (paracetamol) provides the therapeutic effect, while inactive ingredients (excipients) ensure the tablet’s stability, dissolution, and absorption. Knowing these components helps patients and healthcare providers assess potential allergies, interactions, and suitability for specific conditions.
Aingo Pharma prioritizes high-quality formulations, using excipients that enhance bioavailability and minimize adverse effects. By understanding paracetamol’s composition, users can confidently incorporate it into their symptom management plan, ensuring safe and effective relief.
Composition of Paracetamol 650 mg Tablets
Active Ingredient
- Paracetamol (650 mg): A centrally acting analgesic and antipyretic that inhibits prostaglandin synthesis in the brain, reducing pain perception and fever. Each tablet delivers 650 mg, a dose optimized for adults and adolescents over 12 years.
Inactive Ingredients and Their Purpose
Aingo Pharma’s Paracetamol 650 mg Tablets include carefully selected excipients to optimize delivery and stability:
- Starch: Acts as a disintegrant to promote tablet breakdown in the stomach.
- Povidone (Polyvinylpyrrolidone): A binder that ensures tablet cohesion during manufacturing.
- Microcrystalline Cellulose: Provides tablet bulk and aids in uniform drug release.
- Magnesium Stearate: A lubricant for smooth tablet production, ensuring consistent quality.
- Sodium Starch Glycolate: Enhances rapid dissolution, improving absorption speed.
- Talc: An anti-caking agent to maintain tablet texture.
These excipients are generally recognized as safe (GRAS) and used in minimal quantities to avoid side effects. Aingo Pharma’s formulation avoids unnecessary additives, making it suitable for patients with sensitivities.
Strength and Dosage of Components
- Active Component: Each tablet contains 650 mg of paracetamol, a higher dose than standard 500 mg tablets, designed for moderate pain and fever in adults.
- Inactive Components: Present in trace amounts, these support the tablet’s physical and pharmacokinetic properties without contributing to therapeutic effects.
How Paracetamol Works in the Body
Mechanism of Action
Paracetamol’s exact mechanism is not fully elucidated, but it primarily acts in the central nervous system:
- Pain Relief: Inhibits cyclooxygenase (COX) enzymes (particularly COX-2) in the brain, reducing prostaglandin production, which lowers pain signal transmission.
- Fever Reduction: Acts on the hypothalamic thermoregulatory center, promoting heat dissipation through vasodilation and sweating, thus lowering body temperature.
- Minimal Peripheral Effects: Unlike NSAIDs, paracetamol has negligible effects on peripheral COX enzymes, resulting in minimal anti-inflammatory action and reduced gastrointestinal irritation.
Paracetamol’s rapid onset (within 30–60 minutes) and duration of action (4–6 hours) make it ideal for acute symptom relief. Aingo Pharma’s 650 mg tablets ensure a higher peak plasma concentration, enhancing efficacy for moderate pain.
Role of Ingredients in Treatment
- Paracetamol: Directly alleviates pain and fever by modulating central pain and temperature pathways.
- Inactive Ingredients: Facilitate rapid dissolution and absorption, ensuring paracetamol reaches systemic circulation quickly. Aingo Pharma’s use of sodium starch glycolate enhances bioavailability, critical for fast relief.
Pharmacokinetics
- Absorption: Rapidly absorbed in the small intestine, with peak plasma concentrations reached in 30–60 minutes (faster on an empty stomach). Bioavailability is ~70–90%.
- Distribution: Widely distributed, with a volume of distribution of 0.9 L/kg. Crosses the blood-brain barrier to exert central effects; minimal protein binding (20%).
- Metabolism: Primarily hepatic via glucuronidation (50–60%) and sulfation (25–35%). A small fraction (~5–10%) is metabolized by CYP2E1 to form N-acetyl-p-benzoquinone imine (NAPQI), a toxic metabolite detoxified by glutathione. Overdose depletes glutathione, leading to liver damage.
- Excretion: Metabolites excreted in urine, with a half-life of 1.5–3 hours. No significant accumulation with normal dosing.
Aingo Pharma’s formulation optimizes absorption, ensuring consistent plasma levels for effective symptom control.
Conditions Treated by Paracetamol
Therapeutic Indications
Paracetamol 650 mg is indicated for:
- Pain Relief:
- Headaches (tension, migraine-associated).
- Muscle aches (e.g., post-exercise, injury-related).
- Menstrual cramps (dysmenorrhea).
- Toothaches (pre-dental treatment).
- Post-surgical or minor injury pain.
- Fever Reduction:
- Infections (e.g., viral fevers, flu, dengue).
- Post-vaccination fever.
- Inflammatory conditions with fever.
- Adjunctive Therapy: Combined with other medications (e.g., NSAIDs, caffeine) for enhanced pain relief in specific conditions like migraines.
Why Doctors Choose Paracetamol
- First-Line Therapy: Recommended by WHO and Indian guidelines for mild to moderate pain and fever.
- Safe Profile: Minimal gastrointestinal or cardiovascular risks compared to NSAIDs.
- Broad Suitability: Safe for most age groups (with appropriate dosing) and conditions.
- Aingo Pharma Advantage: High-potency 650 mg tablets with rapid dissolution, ideal for acute relief.
Dosage and Administration Guidelines
Recommended Dosage
The following table outlines dosage recommendations for Aingo Pharma’s Paracetamol 650 mg Tablets:
| Condition | Dosage | Frequency | Maximum Daily Dose | Administration Notes |
| Pain (Adults/Adolescents >12) | 650 mg | Every 4–6 hours | 4 g (4000 mg; ~6 tablets) | Take with water; avoid exceeding 4 g/day |
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