Oncology Drives Adoption of Targeted Protein Degradation

The landscape of modern medicine is undergoing a paradigm shift, with targeted protein degradation (TPD) emerging as one of the most revolutionary therapeutic strategies in recent years. Forecasts indicate that the global Targeted Protein Degradation market will grow at a remarkable compound annual growth rate (CAGR) of 21.2% between 2025 and 2035, reaching an estimated USD 3,468.42 million by 2035. This marks a significant leap from its projected market value of USD 546.63 million in 2025. 

What Is Targeted Protein Degradation? 

Targeted protein degradation represents a novel approach in drug development that leverages the body’s innate protein disposal systems to selectively eliminate disease-causing proteins. Unlike traditional therapies that inhibit the activity of proteins, TPD technologies—such as PROTACs (Proteolysis-Targeting Chimeras), molecular glues, and LYTACs (Lysosome-Targeting Chimeras)—completely degrade the target proteins, offering more durable and effective treatment outcomes. 

By co-opting cellular mechanisms like the ubiquitin-proteasome system and lysosomal degradation pathways, TPD tools redirect harmful or malfunctioning proteins to be tagged and disposed of naturally. This “degrade rather than inhibit” approach offers promising avenues in treating diseases previously deemed “undruggable” by conventional therapies. 

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Market Segments:   

By Technology 

PROTAC 

Molecular Glues 

LYTACs 

Others 

By Application 

Drug Discovery 

Therapy Development 

O Cancer 

O Neurology 

 O Infectious Diseases 

 O Cardiovascular Diseases 

 O Others 

 By End-use 

 Pharmaceutical & Biotechnology Companies 

 Academic & Research Institutes 

 Hospital & Clinical Laboratories 

 Others 

Market Drivers Fueling the Growth 

The exceptional growth trajectory of the TPD market is underpinned by a combination of scientific innovation, expanding disease targets, and increasing demand for next-generation therapeutics. Key factors propelling this market include: 

1. Technological Advancements 

Innovations in molecular biology, structural biology, and protein engineering have enabled the development of more precise and potent degraders. The ability to design small molecules that guide target proteins to the degradation machinery opens the door to treating conditions that were previously considered unmanageable. 

2. Rising Burden of Chronic Diseases 

The global rise in chronic conditions such as cancer, neurodegenerative diseases, and autoimmune disorders is increasing demand for innovative treatments. TPD therapies have shown tremendous potential in oncology and are being actively explored in therapeutic areas like Alzheimer’s, Parkinson’s, and rheumatoid arthritis. 

3. Strategic Collaborations and Licensing Deals 

Collaboration between pharmaceutical giants and biotech innovators is accelerating the TPD pipeline. Co-development partnerships are helping to bridge the gap between research and commercialization, ensuring a smoother path to clinical trials and regulatory approval. 

Key Market Players Shaping the Industry 

The competitive landscape of the targeted protein degradation market is both dynamic and rapidly evolving. It includes a healthy mix of established pharmaceutical leaders and emerging biotech companies that are racing to dominate the TPD space. 

Some of the leading players include: 

Arvinas, Inc. – A pioneer in the development of PROTAC-based therapeutics. 

GlaxoSmithKline (GSK) – Actively investing in TPD technologies and partnerships. 

Amgen Inc. – Exploring novel mechani