Gene Synthesis Market is Anticipated to Witness High Growth Owing to Advancement in Gene Engineering Technologies

Gene synthesis refers to chemically synthesizing strands of DNA base-pair by base-pair in the laboratory. It is used to artificially produce genes that can be used for various research and therapeutic applications such as in DNA cloning, site-directed mutagenesis and recombinant protein expression. The accuracy of gene synthesis has improved significantly over the years due to continuous development of oligonucleotide assembly techniques and next generation DNA sequencing technologies. Gene synthesis has enabled a wide range of applications across various industries including biotechnology, pharmaceutical and healthcare. Custom synthesis of genes enables researchers to conduct target gene validation studies and protein engineering experiments with flexibility and control.

The Global Gene Synthesis Market is estimated to be valued at US$ 2.4 Bn in 2024 and is expected to exhibit a CAGR of 18.% over the forecast period 2024 to 2031.

Key Takeaways

Key players - Key players operating in the Gene Synthesis market are Atum, ATDBio Ltd., Bioneer Corporation, Eurofins Scientific, Eurogentec, GenScript Biotech Corporation, Genewiz, Integrated DNA Technologies, Inc., OriGene Technologies, Inc., and Thermo Fisher Scientific, Inc.

Key opportunities - Rising demand for DNA data archiving is expected to create new opportunities for market players to develop data storage solutions based on DNA encoding and synthesis technologies. Advancements in synthetic biology and expansion of the field into new application areas like energy production and environmental remediation also present significant market opportunities.

Global Expansion - Leading gene synthesis companies are expanding globally through acquisitions, partnerships and establishing new research and manufacturing facilities to cater to the rising demand. For instance, GenScript has expanded into APAC and EMEA markets through acquisitions while Eurofins is setting up a new gene synthesis facility in Europe to supplement its existing network.

Market drivers - Rising investments in synthetic biology research is a major market driver. Synthetic biology has emerged as one of the most funded research areas in recent years owing to its diverse applications. Growing adoption of personalized medicine approach and rising demand for DNA cloning and gene mutation services from biotech and pharmaceutical industries is also fueling market growth.

Market restrain - High cost associated with gene synthesis is a major challenge especially for long or complex genes. Researchers prefer traditional cloning techniques for cost-effectiveness which can restrain market potential. Stringent regulatory guidelines for production of genetically modified organisms also negatively impact the market.

Market drivers - Key drivers will include investments in synthetic biology research as this fuels demand for gene synthesis. Additionally, adoption of personalized medicine and need for DNA cloning/mutation services from biotech and pharma also drives the market. Advancement in gene engineering technologies also supports market growth with improved accuracy and lower costs of synthesis over time.

Market restrain - However, high costs for long/complex genes can restrain market as researchers opt for traditional cloning. Stringent regulatory guidelines for genetically modified organisms also negatively impact the market by creating compliance challenges. Market uncertainties from changing regulations pose a key restrain.

Segment Analysis
The gene synthesis market is dominated by the commercial gene synthesis sub segment. Gene synthesis has wide applications in biological and medical research including generation of gene fragments, gene libraries, complete genes, and complex gene constructs. The commercial gene synthesis sub segment accounted for the largest market share in 2021 due to increasing research activity in drug discovery, personalized medicine, and synthetic biology.

Global Analysis
The North America region dominated the gene synthesis market in 2021 and is expected to continue its dominance over the forecast period as well. This is attributed to the presence of major market players and robust research infrastructure in the region. Asia Pacific is expected to exhibit the fastest growth during the forecast period owing to growing investment in synthetic biology and rising focus on precision medicine in countries like China and India.