Itraconazole Dose For Skin Infections

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Itraconazole is a cornerstone in treating fungal skin infections, offering broad-spectrum efficacy and excellent tissue penetration. Aingo Pharma’s Itraconazole Dose For Skin Infections, particularly its 130 mg super-bioavailable capsules, provides superior bioavailability, reduced dosing frequency, and consistent outcomes, making it the preferred choice for recalcitrant dermatophytosis.

Itraconazole Dose For Skin Infections

When it comes to treating stubborn fungal skin infections, Itraconazole remains one of the most prescribed antifungal medications. Its broad-spectrum activity and deep skin penetration make it highly effective for conditions like tinea corporis, tinea cruris, and candidiasis. Aingo Pharma offers a trusted formulation — Itraconazole Capsules 130 mg (Racole-SB 130) — designed with sustained-release technology for optimal absorption and long-lasting relief. In this blog, we’ll explore the ideal Itraconazole Dose For Skin Infections, how Aingo Pharma’s Racole-SB 130 stands out, and why it’s a preferred choice among healthcare professionals.

What Is Itraconazole?

Itraconazole is a broad-spectrum antifungal medication in the triazole class, used to treat various fungal infections, including skin infections like dermatophytosis (ringworm, athlete’s foot, jock itch), pityriasis versicolor, and cutaneous candidiasis. It works by inhibiting ergosterol synthesis, a vital component of fungal cell membranes, leading to fungal cell death.

Aingo Pharma’s itraconazole capsules (130 mg and other strengths) are designed to deliver potent antifungal action with high bioavailability, making them a trusted choice for dermatologists and patients.

Overview of Itraconazole and Its Use

Itraconazole is highly effective for skin infections that are resistant to topical treatments or require systemic therapy. Aingo Pharma’s itraconazole formulations, available as capsules and oral solutions, ensure optimal absorption and tissue penetration, particularly in the skin and nails. Its long half-life and ability to persist in tissues make it ideal for treating chronic or recalcitrant fungal infections, such as those prevalent in India due to increasing antifungal resistance.

Why Understanding Composition Matters

The composition of itraconazole, including its active and inactive ingredients, determines its efficacy, safety, and tolerability. Understanding these components helps patients and doctors assess potential allergies, drug interactions, and suitability for specific conditions. Aingo Pharma’s itraconazole is formulated with high-quality excipients to enhance stability and absorption, ensuring consistent therapeutic outcomes.

Itraconazole Composition at a Glance

Active Ingredients in Itraconazole

Itraconazole: A triazole antifungal that inhibits lanosterol 14-α-demethylase, disrupting ergosterol synthesis in fungal cell membranes.

Inactive Ingredients & Their Purpose

Aingo Pharma’s itraconazole capsules (e.g., 130 mg) may include:

Hypromellose: Capsule shell for controlled release.
Polyethylene Glycol: Enhances solubility and absorption.
Microcrystalline Cellulose: Stabilizes the formulation.
Magnesium Stearate: Lubricant for manufacturing consistency.

In oral solutions, hydroxypropyl-β-cyclodextrin improves solubility but may cause osmotic diarrhea in some patients. Aingo Pharma ensures minimal use of excipients to reduce side effects while maintaining efficacy.

Strength and Dosage of Each Component

Capsules: Available in 100 mg, 130 mg (Aingo Pharma’s super-bioavailable formulation), and other strengths.
Oral Solution: 10 mg/mL. The active ingredient (itraconazole) is dosed based on the infection, while inactive ingredients support delivery without therapeutic effects.

How Itraconazole Works in the Body

Itraconazole Dose For Skin Infections targets fungal cell membranes by inhibiting ergosterol synthesis, causing leakage and fungal death. Its active metabolite, hydroxyitraconazole, enhances antifungal activity. The drug’s lipophilic nature allows it to concentrate in skin (3–10 times higher than plasma) and nails, ensuring prolonged action even after treatment ends. Aingo Pharma’s super-bioavailable itraconazole (SB ITZ) achieves higher serum and skin concentrations, improving efficacy for resistant infections.

Role of Each Ingredient in Treating Skin Infections

Itraconazole: Directly eliminates dermatophytes (e.g., Trichophyton, Microsporum) and yeasts (e.g., Candida, Malassezia).
Inactive Ingredients: Ensure effective delivery to infected tissues, with Aingo Pharma’s formulations optimized for minimal variability.

Pharmacokinetics: Absorption, Distribution, Metabolism, and Excretion

Absorption: Capsules require a full meal for optimal absorption (55% bioavailability); SB ITZ (e.g., Aingo Pharma’s 130 mg) offers higher bioavailability (~80%). Oral solutions are taken on an empty stomach.
Distribution: Highly protein-bound (>99%), concentrates in skin, nails, and fatty tissues. Negligible cerebrospinal fluid penetration limits CNS use.
Metabolism: Hepatic via CYP3A4, producing over 30 metabolites, including active hydroxyitraconazole.
Excretion: Primarily via bile and feces (54%), with <1% in urine. Skin concentrations persist for 2–4 weeks, nails up to 6 months.

What Conditions Does Itraconazole Treat?

Itraconazole is indicated for:

Skin Infections: Tinea corporis, tinea cruris, tinea pedis, pityriasis versicolor, cutaneous candidiasis.
Nail Infections: Onychomycosis.
Systemic Infections: Aspergillosis, blastomycosis, histoplasmosis.
Mucosal Infections: Oral/esophageal candidiasis (oral solution).

Aingo Pharma’s itraconazole is particularly effective for recalcitrant dermatophytosis, addressing India’s growing challenge of antifungal resistance.

Why Doctors Prescribe Itraconazole

Broad-spectrum activity against dermatophytes, yeasts, and molds.
High penetration into skin and nails.
Effective for both superficial and systemic infections.
Aingo Pharma’s SB ITZ offers superior bioavailability, reducing dosing frequency and improving patient compliance.

Safety & Warnings

Is the Composition of Itraconazole Safe for Everyone?

Itraconazole is generally safe but contraindicated in:

Hypersensitivity to azoles or excipients.
Congestive heart failure (risk of exacerbation).
Pregnancy (except for life-threatening infections).

Who Should Avoid This Medicine Based on Its Composition?

Patients with liver/kidney disease (requires monitoring).
Those on CYP3A4-metabolized drugs (e.g., statins, quinidine).
Women of childbearing age (use contraception during and 2 months post-treatment).

Possible Allergic Reactions to Certain Ingredients

Rare reactions (rash, hives, anaphylaxis) to itraconazole or cyclodextrin.
Cross-sensitivity with other azoles (e.g., fluconazole).

Comparison & Alternatives

Comparison with Other Brands: Is the Composition Different?

Aingo Pharma’s itraconazole, particularly its 130 mg SB ITZ capsules, offers superior bioavailability compared to conventional itraconazole (CITZ) brands like Sporanox. While active ingredients are identical, Aingo Pharma’s formulation uses advanced SUBA® technology to enhance absorption, reducing inter-patient variability and food dependency.

Alternative Medicines with Similar Composition

Fluconazole: Effective for candidiasis but less active against Aspergillus.
Terbinafine: Preferred for dermatophytosis; targets squalene epoxidase.
Voriconazole/Posaconazole: Broader spectrum for systemic infections.

Generic vs Branded Composition: What’s the Difference?

Generics contain the same active ingredient but may differ in excipients, affecting bioavailability. Aingo Pharma’s SB ITZ ensures bioequivalence with branded versions, with enhanced absorption for better outcomes.