Why Glioblastoma (GBM) Remains a Challenge
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults, yet it is also one of the most difficult to treat. Its rapid growth, invasive spread, and genetic complexity render many treatments ineffective, leading to a high recurrence rate and low survival beyond 15 months.
Expanding Horizons in the Glioblastoma Market by Treatment
The glioblastoma market by treatment is evolving as the scientific community shifts focus from conventional therapies to novel, multi-targeted approaches. Drug developers are exploring immunotherapy, targeted therapies, and device-assisted treatments such as tumor-treating fields to complement or replace chemotherapy.
Market interest is also being driven by improved diagnostic techniques and biomarker-based stratification, allowing for better patient selection in clinical trials.
Redefining Glioblastoma Treatment
New advances in glioblastoma treatment include personalized medicine techniques and drug regimens designed to bypass resistance mechanisms. Strategies like RNA-based therapeutics, anti-angiogenic agents, and CAR-T cells are all under investigation, with some already entering late-stage clinical trials.
Multimodal therapy—blending surgery, radiation, and new agents—is becoming more common as we better understand tumor behavior.
Paxalisib: A Promising Drug Candidate
Paxalisib stands out among investigational treatments. Developed by Kazia Therapeutics, this PI3K inhibitor has demonstrated potential in GBM cases with poor response to temozolomide. Its blood-brain barrier penetration and tumor-specific action make it a strong candidate for future use, particularly in patients with limited alternatives.
As results from ongoing trials become available, paxalisib may offer a vital new option in the fight against glioblastoma.
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