Emerging BKV Infection Therapeutics Market to Rapidly Grow Driven By Rising Adoption of Novel Treatments
BKV infection is a serious complication for kidney and stem cell transplant recipients, causing complications such as hemorrhagic cystitis (HC) and nephropathy. Currently, no FDA approved treatment exists for BKV infections. Existing off-label therapies include modulation of immunosuppression, intravenous immunoglobulin, cidofovir and leflunomide. However, these are associated with safety issues and limited efficacy. This has boosted research efforts to develop first-in-class therapies specifically targeting BKV.
The BK Virus (BKV) infection market is estimated to be valued at USD 34 Mn in 2024 and is expected to reach USD 389 Mn by 2031, growing at a compound annual growth rate (CAGR) of 41.7% from 2024 to 2031.
Key Takeaways
Key players operating in the BKV infection therapeutics market are AlloVir,Amplyx Pharmaceuticals, Societas Therapeutiae. AlloVir's lead candidate posoleucel is an antiviral allogeneic T cell therapy in Phase 3 trials for treating BK viremia in kidney transplant recipients. If approved, it will be the first approved therapy.
The BK Virus (BKV) Infection Market growing incidence of BKV infections post-transplantation due to increasing number of transplant procedures and use of immunosuppressants is a major factor driving the market growth. According to WHO, over 100,000 solid organ transplants are performed annually worldwide.
Novel therapeutic approaches harnessing targeted antiviral mechanisms, viral-specific immunotherapy and innate immunity modulation have potential to address the unmet need. Companies are developing therapies based on monoclonal antibodies, small molecules, CRISPR and RNAi technology.
Market Trends
Increased focus on therapeutics targeting BK polyomavirus pathogenesis and replication cycle. Drugs inhibiting viral attachment, entry and replication are being evaluated.
Combination therapy approaches combining targeted antiviral drugs with immunotherapies to synergistically treat infection as well as prevent recurrence are gaining traction.
Market Opportunities
Emerging markets in Asia Pacific and Latin America are expected to provide lucrative opportunities driven by rapid infrastructural development and healthcare reforms promoting organ transplantation.
Establishing early diagnostic biomarkers to identify high-risk transplant recipients for prophylactic interventions represents an opportunity area. Companion diagnostics may aid patient selection and monitoring treatment response.
Impact of COVID-19 on BK Virus (BKV) Infection Market Growth
The COVID-19 pandemic has had a significant impact on the BK Virus (BKV) Infection market. During the initial phases of the pandemic in 2020, most hospitals and healthcare facilities focussed their resources on treating COVID-19 patients. As a result, non-essential procedures and treatments were postponed. This had a negative impact on the diagnosis and treatment of BKV infection, resulting in reduced demand for related drugs and diagnostic tests.
The pandemic has also disrupted global supply chains. Several manufacturing facilities were temporarily shut down due to lockdowns. This led to shortages of raw materials and finished products.drug production and distribution were delayed.
Geographical regions of concentration
North America accounts for the largest share of the global BKV Infection market currently, in terms of value. This is attributed to factors like the large solid organ transplant patient population, growing incidence rates, widespread healthcare coverage and reimbursements supporting diagnostic testing and treatment access. Several key market players are also headquartered in the region, aiding product availability.
Fastest growing region
The Asia Pacific region has shown rising market attractiveness in recent years. The patient pool needing transplantation is increasing rapidly as a result of economic growth, lifestyle changes and an aging population. Countries like India, China and Japan now conduct a large number of transplants annually. Increasing healthcare investments, expanding diagnostic capabilities and growing medical tourism are supporting market expansion in the Asia Pacific region, which is expected to be the fastest growing over the forecast period.
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Ravina Pandya, Content Writer, has a strong foothold in the market research industry. She specializes in writing well-researched articles from different industries, including food and beverages, information and technology, healthcare, chemical and materials, etc.
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