Downstream Processing Market is Anticipated to Witness Moderate Growth Owing to Increasing Focus on Bioprocessing

Downstream Processing Market is Anticipated to Witness Moderate Growth Owing to Increasing Focus on Bioprocessing

The downstream processing market involves purification and separation process of biosolecules, therapeutic proteins, and other products derived from natural sources. Downstream processing helps remove impurities, reduce volume, and isolate the target biopharmaceutical product. It has become an integral part of the overall biomanufacturing process as it ensures the integrity, safety, and efficacy of biologic drugs and vaccines. The process utilizes various methods including chromatography, filtration, centrifugation, and solid-liquid separation that allow concentration of desired molecules and elimination of contaminants. Downstream processing plays a crucial role in attaining the required quality specifications for biologics.

The Global Downstream Processing Market is estimated to be valued at US$ 246.2 Mn in 2024 and is expected to exhibit a CAGR of 2.6% over the forecast period 2024 to 2031.

The increased development of large molecule biologic drugs and vaccines have stimulated the demand for downstream processing in recent years. In addition, the growing focus of pharmaceutical industry on single-use technologies and continuous manufacturing further supports market growth.

Key Takeaways

Key players operating in the downstream processing market are Merck KGaA, Thermo Fisher Scientific Inc., GE Healthcare, Sartorius Stedim Biotech S.A., Repligen Corporation, Pall Corporation, Eppendorf AG, Agilent Technologies, Inc., Waters Corporation, Shimadzu Corporation, Bio-Rad Laboratories, Inc., Avantor Performance Materials, LLC, Tosoh Corporation, Column Technology Inc., Purolite, W.R. Grace & Co., Asahi Kasei Corporation, Novasep Holding S.A.S, and Boehringer Ingelheim. These players are focusing on new product launches, strategic collaborations and mergers to gain higher market share.

The rising demand for Downstream Processing Market Demand biologics, cell and gene therapies provide significant opportunities in the market. Emerging economies in Asia Pacific and Latin America regions offer potential for market expansion due to presence of less stringent regulations and growing biopharmaceutical industry. Global players are setting up advanced manufacturing units in these regions to cater rising demand.

In terms of industry expansions, many leading players in 2020 have invested or partnered with Asian biopharma companies to establish new production sites and expand existing facilities. For instance, Merck opened a new downstream processing and fill/finish plant in Singapore. Sartorius setup expanded production facilities China and India. Such strategic moves aim to serve high growth biomanufacturing hubs and reduce trade barriers.

Market drivers and restraints

Market Drivers:
- Growing production of complex biologics such as monoclonal antibodies, vaccines, and recombinant proteins drives need for efficient downstream processing
- Increasing trend of outsourcing biological manufacturing activities to contract manufacturing organizations augments market growth
- Rise in adoption of single-use technologies simplifies downstream workflow and reduces costs for end-users

Market Restraints:
- High costs associated with downstream processing equipment and solutions limits investments from small biomolecule companies
- Stringent regulatory guidelines for downstream processing approvals increase compliance burden on manufacturers

Segment Analysis
The downstream processing market is dominating by the chromatography segment owing to its wide application in the purification and separation of biomolecules. Chromatography helps in reducing the complexity of biological samples and isolating specific components which has increased its demand significantly. Within chromatography, affinity chromatography dominates as it provides high selectivity and purity for large-scale purification of biological products.

Global Analysis
North America holds the largest share in the downstream processing market due to increasing research funding to support drug discovery and development activities in the region. The region is also witnessing significant initiatives by various government and private organizations toward developing large-scale production facilities that utilize downstream processing. Asia Pacific is expected to witness the highest growth during the forecast period due to the rising biopharmaceutical manufacturing industry and improving healthcare infrastructure. Countries like China, Japan, South Korea and India are emerging as major contributors to the regional market growth.

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Ravina Pandya, Content Writer, has a strong foothold in the market research industry. She specializes in writing well-researched articles from different industries, including food and beverages, information and technology, healthcare, chemical and materials, etc. (https://www.linkedin.com/in/ravina-pandya-1a3984191)