One of the significant advantages of Gas Chromatography is its exceptional sensitivity, allowing for the analysis of even trace amounts of compounds in complex mixtures. This sensitivity is further enhanced by the use of detectors that respond selectively to the analytes of interest. Common detectors in gas chromatography include flame ionization detectors (FID), thermal conductivity detectors (TCD), electron capture detectors (ECD), and mass spectrometers (MS). FID is widely used due to its high sensitivity, broad applicability, and excellent linear response.
TCD is a universal detector that responds to changes in thermal conductivity, making it suitable for non-destructive detection of various compounds. ECD is highly selective for compounds with electronegative functional groups, making it ideal for the analysis of halogenated compounds and pesticides. Mass spectrometry, coupled with Gas Chromatography (GC-MS), provides both separation and identification capabilities, offering unmatched sensitivity and selectivity for complex sample analysis. Gas chromatography finds applications in diverse fields.
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