Combination therapies involve the simultaneous use of multiple treatment modalities to maximize efficacy and overcome resistance mechanisms. Combinations of targeted therapies, immunotherapies, and chemotherapy have shown promising results in clinical trials. For instance, the combination of BRAF and MEK inhibitors with immune checkpoint inhibitors has demonstrated improved response rates and overall survival in patients with BRAF-mutant melanoma. Ongoing research is focused on identifying optimal combinations and Melanoma Treatment sequences.
Precision medicine aims to individualize treatment by considering a patient's unique genetic profile, tumor characteristics, and clinical features. Molecular profiling techniques, such as next-generation sequencing, allow for comprehensive analysis of genetic alterations in melanoma tumors. This information helps identify specific therapeutic targets and predict response to treatment. Additionally, liquid biopsies, which analyze circulating tumor DNA, enable real-time monitoring of Melanoma Treatment response and the detection of emerging resistance.
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